Associate Professor of the Oral Pathology Department, School of Dentistry, University of Buenos Aires
Chapter 2 “Biological Aspects”
Titanium and corrosion – Fact or Vision?
Humans are exposed to different types of particles that can enter the body mainly through inhalation, ingestion and/or the skin. In view of the widespread use of biomaterials in medicine, another potential source of systemic contamination with micro (MPs, >100nm) and /or nanoparticles (NPs, 1-100nm) is the surface of metallic biomedical devices. Titanium is widely used in the manufacture of dental and orthopedic implants due to its excellent biocompatibility. It is a highly reactive metal, and on exposure to air or fluids it rapidly develops a passivating layer of titanium dioxide (TiO2). However, as a result of electrochemical corrosion processes, frictional wear (tribology), or a synergistic combination of the two, ions/particles may be released from metal implants. The combined effect of mechanical, biochemical, and electrochemical factors is known as tribocorrosion.
The side effects caused by titanium ions/ micro- and nanoparticles in biological systems have been ignored mostly, as this metal is widely considered to be inert. Research in human samples conducted by our group has shown the presence of titanium particles in peri-implant tissue around failed human dental implants, in oral mucosa in contact with implant cover screws, in cells exfoliated from peri-implant oral mucosa around titanium dental implants, and in reactive lesions in the peri-implant mucosa. In addition, our studies in experimental animal models demonstrated deposition of titanium micro and nanoparticles and the presence of a tissue response to these particle deposits.
This presentation will address the local and systemic effects of tribocorrosion of titanium, as shown by our studies in experimental animals and human tissues.
DMD Doctor of Dental Medicine, National University of Córdoba, Argentina
PhD in Dentistry, National University of Córdoba, Argentina.
Head Professor of the Oral Pathology Department, School of Dentistry, University of Buenos Aires, Argentina.
Associate Researcher, Career of Scientific and Technological Researcher, National Council of Scientific and Technological Research (CONICET), Argentina.
Main research area: Biomaterials (metallic implants and bone substitutes). Biological effect of metallic implant tribocorrosion.
Person in charge of the Biomaterials Laboratory of the Oral Pathology Department, School of Dentistry, University of Buenos Aires, Argentina.
Author of 33 full scientific papers published in international peer-reviewed indexed journals, including theJournal Biomedical Materials Research, Journal Materials Science: Materials in Medicine, Journal of Physics: Conference Series, Implant Dentistry, International Journal of Oral and Maxillofacial Surgery, Journal of Periodontology, Eur J Oral Sci, andMRS Bulletin, among others, 2 scientific communications, 2 book chapters, and 70 works published as abstracts.
Presenting author at 70 local scientific meetings and 19 international congresses(Canada, US, Japan, Australia, Germany, Holland, Spain, China).
Director of research grants from national funding agencies
Reviewer for a number of international journals, including theJ Dent Res, J Biomed Mater Res A,Spectrochim Acta A Mol Biomol Spectrosc, Acta Biomater, Int J Oral Maxillofac Implants, Applied Mater & Interfac, Surf Interface Anal, Journal of Periodontol, Case Rep Dent, Acta Odontol Latinoam, and J Med Case Rep among others.
Active member of the International Association for Dental Research
President of the Argentine Society of Dental Research (Argentine Division of the International Association for Dental Research) from 2015 to 2016.