Senior Research Scientist; Group Leadet G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Prosthodontics, Medical Center – University of Freiburg
Chapter 2 “Biological aspects”
Zirconia implant topography changes: Possibilities and risks
A relevant issue in implant biomaterial research is the creation of defined surface properties to better control the target cell-biomaterial interactions. Regarding oral implantology, the impact of biomaterial surface properties on bone tissue response has been recognized already in the early 1980s. With emphasis on these properties, innumerable surface modifications of implant materials have been introduced up till now, all of them aiming at to ensure a long-lasting bone-to-implant interface. With respect to surface topography, there is a wide consensus today that microrough implant surfaces better support osteoblast-triggered hard tissue integration than smooth surfaces. However, with the development of multitude surface modification methods to roughen the ceramic surfaces, implants with similar average surface roughness, but different micro- and nanotopographical properties were produced, provoking different cellular reactions. This suggests that other details of the surface structure can be more determining on cell-biomaterial interaction-derived cell fate than their roughness degree. This lecture will provide an overview of state-of-the-art surface modification techniques of zirconia implants and the resulting topographies as well as of the current knowledge on the link between specific surface topography parameters and the cell response at the tissue-implant interface. The goal is to raise the awareness for the significant role of distinct structural micro- and/or nanoscale features of implants, which arise from the different surface modification techniques, in influencing target cell behavior and thus, essentially contribute to implant tissue integration.
Dr. Brigitte Altmann studied Biology in Karlsruhe, Germany, and received her Ph.D. degree from the University Heidelberg, Germany.
After completing her Ph.D. at the Institute for Biological Interfaces-1 (IBG-1, Karlsruhe Institute of Technology (KIT), Germany) she continued her work at the IBG-1 from 2007 to 2009 as postdoc. Since 2010, she works at the University Medical Center Freiburg (Germany) in the Department of Prosthodontics and amongst them in the Department of Maxillofacial Surgery, first as postdoc, now as Senior Research Scientist and Group Leader in the Research Association G.E.R.N. (Tissue Replacement, Regeneration and Neogenesis) at the University Medical Center Freiburg.
Dr. Brigitte Altmann is particularly interested in the research field of cell biology-inspired regenerative medicine with focus on cell-material interactions, and has a long-term experience in 2D- and 3D- in vitro cell models of soft and hard tissues.